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desvenlafaxine will enhance the amount or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by up to 50%; no dosage adjustment necessary with desvenlafaxine doses 7 consecutive times right awa